All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:11 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs Wsh |
| 2 | Nick Chubb | Cle vs Det |
| 3 | Austin Ekeler | LAC vs Pit |
| 4 | Dalvin Cook | Min vs GB |
| 5 | Najee Harris | Pit @ LAC |
| 6 | Jonathan Taylor | Ind @ Buf |
| 7 | A.J. Dillon | GB @ Min |
| 8 | Ezekiel Elliott | Dal @ KC |
| 9 | Joe Mixon | Cin @ LV |
| 10 | Leonard Fournette | TB vs NYG |
| 11 | James Conner | Ari @ Sea |
| 12 | Mark Ingram | NO @ Phi |
| 13 | D'Andre Swift | Det @ Cle |
| 14 | Jeff Wilson | SF @ Jax |
| 15 | Saquon Barkley (GTD) | NYG @ TB |
| 16 | Michael Carter | NYJ vs Mia |
| 17 | Josh Jacobs | LV vs Cin |
| 18 | David Montgomery | Chi vs Bal |
| 19 | James Robinson (GTD) | Jax vs SF |
| 20 | Myles Gaskin | Mia @ NYJ |
| Rank | Player | Match |
| 21 | Antonio Gibson | Wsh @ Car |
| 22 | Alex Collins | Sea vs Ari |
| 23 | D'Onta Foreman | Ten vs Hou |
| 24 | Miles Sanders | Phi vs NO |
| 25 | Darrel Williams | KC vs Dal |
| 26 | Zack Moss | Buf vs Ind |
| 27 | D'Ernest Johnson | Cle vs Det |
| 28 | Clyde Edwards-Helaire | KC vs Dal |
| 29 | Adrian Peterson | Ten vs Hou |
| 30 | Tony Pollard | Dal @ KC |
| 31 | Kenyan Drake | LV vs Cin |
| 32 | Devin Singletary | Buf vs Ind |
| 33 | Devonta Freeman | Bal @ Chi |
| 34 | David Johnson | Hou @ Ten |
| 35 | J.D. McKissic | Wsh @ Car |
| 36 | Nyheim Hines | Ind @ Buf |
| 37 | Latavius Murray (GTD) | Bal @ Chi |
| 38 | Jamaal Williams (GTD) | Det @ Cle |
| 39 | Ty Johnson | NYJ vs Mia |
| 40 | Eli Mitchell (GTD) | SF @ Jax |
