All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:17 AM ET.
| Rank | Player | Match |
| 1 | Najee Harris | Pit vs Det |
| 2 | Dalvin Cook | Min @ LAC |
| 3 | Jonathan Taylor | Ind vs Jax |
| 4 | Austin Ekeler | LAC vs Min |
| 5 | Christian McCaffrey | Car @ Ari |
| 6 | D'Andre Swift | Det @ Pit |
| 7 | Aaron Jones | GB vs Sea |
| 8 | Ezekiel Elliott | Dal vs Atl |
| 9 | Cordarrelle Patterson | Atl @ Dal |
| 10 | James Conner | Ari vs Car |
| 11 | D'Ernest Johnson | Cle @ NE |
| 12 | Leonard Fournette | TB @ Wsh |
| 13 | Mark Ingram | NO @ Ten |
| 14 | Darrell Henderson | LAR @ SF |
| 15 | Josh Jacobs | LV vs KC |
| 16 | Eli Mitchell | SF vs LAR |
| 17 | Michael Carter | NYJ vs Buf |
| 18 | Melvin Gordon | Den vs Phi |
| 19 | Darrel Williams | KC @ LV |
| 20 | James Robinson (GTD) | Jax @ Ind |
| Rank | Player | Match |
| 21 | Antonio Gibson | Wsh vs TB |
| 22 | Zack Moss | Buf @ NYJ |
| 23 | Javonte Williams | Den vs Phi |
| 24 | Brandon Bolden | NE vs Cle |
| 25 | Rhamondre Stevenson (GTD) | NE vs Cle |
| 26 | Alex Collins | Sea @ GB |
| 27 | Devin Singletary | Buf @ NYJ |
| 28 | J.D. McKissic | Wsh vs TB |
| 29 | Tony Pollard | Dal vs Atl |
| 30 | Mike Davis | Atl @ Dal |
| 31 | Adrian Peterson | Ten vs NO |
| 32 | A.J. Dillon | GB vs Sea |
| 33 | Nyheim Hines | Ind vs Jax |
| 34 | Jeremy McNichols | Ten vs NO |
| 35 | Jordan Howard | Phi @ Den |
| 36 | Kenyan Drake | LV vs KC |
| 37 | Boston Scott | Phi @ Den |
| 38 | Ty Johnson | NYJ vs Buf |
| 39 | Sony Michel | LAR @ SF |
| 40 | Eno Benjamin | Ari vs Car |
