All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 8:26 AM ET.
| Rank | Player | Match |
| 1 | Derrick Henry | Ten @ Jax |
| 2 | Aaron Jones | GB @ Cin |
| 3 | Alvin Kamara | NO @ Wsh |
| 4 | Austin Ekeler | LAC vs Cle |
| 5 | Saquon Barkley | NYG @ Dal |
| 6 | Ezekiel Elliott | Dal vs NYG |
| 7 | Najee Harris | Pit vs Den |
| 8 | D'Andre Swift | Det @ Min |
| 9 | James Robinson | Jax vs Ten |
| 10 | Damien Williams | Chi @ LV |
| 11 | Jonathan Taylor | Ind @ Bal |
| 12 | Antonio Gibson | Wsh vs NO |
| 13 | Nick Chubb | Cle @ LAC |
| 14 | Leonard Fournette | TB vs Mia |
| 15 | Clyde Edwards-Helaire | KC vs Buf |
| 16 | Dalvin Cook | Min vs Det |
| 17 | Chuba Hubbard | Car vs Phi |
| 18 | James Conner | Ari vs SF |
| 19 | Josh Jacobs | LV vs Chi |
| 20 | Miles Sanders | Phi @ Car |
| Rank | Player | Match |
| 21 | Mike Davis | Atl @ NYJ |
| 22 | Alexander Mattison | Min vs Det |
| 23 | Michael Carter | NYJ vs Atl |
| 24 | Kareem Hunt | Cle @ LAC |
| 25 | Damien Harris | NE @ Hou |
| 26 | Jamaal Williams | Det @ Min |
| 27 | Melvin Gordon | Den @ Pit |
| 28 | Javonte Williams | Den @ Pit |
| 29 | Latavius Murray | Bal vs Ind |
| 30 | Joe Mixon (GTD) | Cin vs GB |
| 31 | Myles Gaskin | Mia @ TB |
| 32 | Tony Pollard | Dal vs NYG |
| 33 | Devin Singletary | Buf @ KC |
| 34 | Mark Ingram | Hou vs NE |
| 35 | Kenneth Gainwell | Phi @ Car |
| 36 | Kenyan Drake | LV vs Chi |
| 37 | Eli Mitchell | SF @ Ari |
| 38 | Zack Moss | Buf @ KC |
| 39 | David Johnson | Hou vs NE |
| 40 | J.D. McKissic | Wsh vs NO |
