All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 10:27 AM ET.
| Rank | Player | Match |
| 1 | Derrick Henry | Ten vs Ind |
| 2 | Dalvin Cook (GTD) | Min vs Sea |
| 3 | Alvin Kamara | NO @ NE |
| 4 | Aaron Jones | GB @ SF |
| 5 | Saquon Barkley | NYG vs Atl |
| 6 | Najee Harris | Pit vs Cin |
| 7 | Austin Ekeler | LAC @ KC |
| 8 | Joe Mixon | Cin @ Pit |
| 9 | Nick Chubb | Cle vs Chi |
| 10 | Chris Carson | Sea @ Min |
| 11 | D'Andre Swift | Det vs Bal |
| 12 | Ezekiel Elliott | Dal vs Phi |
| 13 | Jonathan Taylor | Ind @ Ten |
| 14 | Antonio Gibson | Wsh @ Buf |
| 15 | Miles Sanders | Phi @ Dal |
| 16 | David Montgomery | Chi @ Cle |
| 17 | Clyde Edwards-Helaire | KC vs LAC |
| 18 | Damien Harris | NE vs NO |
| 19 | James Robinson | Jax vs Ari |
| 20 | Chase Edmonds | Ari @ Jax |
| Rank | Player | Match |
| 21 | Melvin Gordon | Den vs NYJ |
| 22 | Mike Davis | Atl @ NYG |
| 23 | Kenyan Drake | LV vs Mia |
| 24 | Myles Gaskin | Mia @ LV |
| 25 | Leonard Fournette | TB @ LAR |
| 26 | Trey Sermon | SF vs GB |
| 27 | Kareem Hunt | Cle vs Chi |
| 28 | Javonte Williams | Den vs NYJ |
| 29 | Ty'Son Williams | Bal @ Det |
| 30 | Devin Singletary | Buf vs Wsh |
| 31 | Darrell Henderson | LAR vs TB |
| 32 | James White | NE vs NO |
| 33 | James Conner | Ari @ Jax |
| 34 | Jamaal Williams | Det vs Bal |
| 35 | Tony Pollard | Dal vs Phi |
| 36 | Michael Carter | NYJ @ Den |
| 37 | Sony Michel | LAR vs TB |
| 38 | Nyheim Hines | Ind @ Ten |
| 39 | J.D. McKissic | Wsh @ Buf |
| 40 | Kenneth Gainwell | Phi @ Dal |
