All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 8:18 AM ET.
| Rank | Player | Match |
| 1 | Dalvin Cook | Min vs Car |
| 2 | Alvin Kamara | NO @ Den |
| 3 | Aaron Jones | GB vs Chi |
| 4 | Josh Jacobs | LV @ Atl |
| 5 | Nick Chubb | Cle @ Jax |
| 6 | Derrick Henry | Ten @ Ind |
| 7 | James Robinson | Jax vs Cle |
| 8 | Miles Sanders | Phi vs Sea |
| 9 | Austin Ekeler | LAC @ Buf |
| 10 | Mike Davis | Car @ Min |
| 11 | Chris Carson | Sea @ Phi |
| 12 | Nyheim Hines | Ind vs Ten |
| 13 | Giovani Bernard (GTD) | Cin vs NYG |
| 14 | Kareem Hunt | Cle @ Jax |
| 15 | David Montgomery (GTD) | Chi @ GB |
| 16 | Brian Hill | Atl vs LV |
| 17 | Clyde Edwards-Helaire | KC @ TB |
| 18 | Wayne Gallman | NYG @ Cin |
| 19 | Kenyan Drake | Ari @ NE |
| 20 | Raheem Mostert (GTD) | SF @ LAR |
| Rank | Player | Match |
| 21 | Ronald Jones | TB vs KC |
| 22 | Damien Harris | NE vs Ari |
| 23 | James White | NE vs Ari |
| 24 | Leonard Fournette | TB vs KC |
| 25 | Jordan Wilkins | Ind vs Ten |
| 26 | Jamaal Williams | GB vs Chi |
| 27 | Darrell Henderson | LAR vs SF |
| 28 | Zack Moss | Buf vs LAC |
| 29 | Frank Gore | NYJ vs Mia |
| 30 | Melvin Gordon | Den vs NO |
| 31 | Chase Edmonds | Ari @ NE |
| 32 | Devin Singletary | Buf vs LAC |
| 33 | Jerick McKinnon | SF @ LAR |
| 34 | Latavius Murray | NO @ Den |
| 35 | Phillip Lindsay (GTD) | Den vs NO |
| 36 | Ty Johnson | NYJ vs Mia |
| 37 | Malcolm Brown | LAR vs SF |
| 38 | Matt Breida (GTD) | Mia @ NYJ |
| 39 | Cam Akers | LAR vs SF |
| 40 | Ito Smith | Atl vs LV |
