All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sun 9:52 AM ET.
| Rank | Player | Match |
| 1 | Dalvin Cook | Min vs Dal |
| 2 | Alvin Kamara | NO vs Atl |
| 3 | Aaron Jones | GB @ Ind |
| 4 | Derrick Henry | Ten @ Bal |
| 5 | Josh Jacobs | LV vs KC |
| 6 | Miles Sanders | Phi @ Cle |
| 7 | James Robinson | Jax vs Pit |
| 8 | Ezekiel Elliott (GTD) | Dal @ Min |
| 9 | Mike Davis | Car vs Det |
| 10 | James Conner | Pit @ Jax |
| 11 | Giovani Bernard | Cin @ Wsh |
| 12 | Nick Chubb | Cle vs Phi |
| 13 | Antonio Gibson | Wsh vs Cin |
| 14 | Kalen Ballage | LAC vs NYJ |
| 15 | Duke Johnson | Hou vs NE |
| 16 | Todd Gurley | Atl @ NO |
| 17 | Ronald Jones | TB vs LAR |
| 18 | Kareem Hunt | Cle vs Phi |
| 19 | Clyde Edwards-Helaire | KC @ LV |
| 20 | J.D. McKissic | Wsh vs Cin |
| Rank | Player | Match |
| 21 | Leonard Fournette | TB vs LAR |
| 22 | Adrian Peterson | Det @ Car |
| 23 | Salvon Ahmed | Mia @ Den |
| 24 | Nyheim Hines | Ind vs GB |
| 25 | Melvin Gordon | Den vs Mia |
| 26 | La'Mical Perine | NYJ @ LAC |
| 27 | Damien Harris (que) | NE @ Hou |
| 28 | Rex Burkhead | NE @ Hou |
| 29 | Darrell Henderson | LAR @ TB |
| 30 | Kerryon Johnson | Det @ Car |
| 31 | Jonathan Taylor | Ind vs GB |
| 32 | Jamaal Williams | GB @ Ind |
| 33 | J.K. Dobbins | Bal vs Ten |
| 34 | Latavius Murray | NO vs Atl |
| 35 | Joshua Kelley | LAC vs NYJ |
| 36 | Mark Ingram (GTD) | Bal vs Ten |
| 37 | Le'Veon Bell | KC @ LV |
| 38 | Phillip Lindsay (GTD) | Den vs Mia |
| 39 | James White | NE @ Hou |
| 40 | Jordan Wilkins | Ind vs GB |
