All position ranks are: QB RB WR TE FLEX D
These rankings were updated as of Sun 10:37 AM ET.
| Rank | Player | Match |
| 1 | Alvin Kamara | NO @ Det |
| 2 | Ezekiel Elliott | Dal vs Cle |
| 3 | Dalvin Cook | Min @ Hou |
| 4 | Aaron Jones | GB vs Atl |
| 5 | Josh Jacobs | LV vs Buf |
| 6 | Miles Sanders | Phi @ SF |
| 7 | Clyde Edwards-Helaire | KC vs NE |
| 8 | Austin Ekeler | LAC @ TB |
| 9 | Kenyan Drake | Ari @ Car |
| 10 | Joe Mixon (que) | Cin vs Jax |
| 11 | Jonathan Taylor | Ind @ Chi |
| 12 | David Johnson | Hou vs Min |
| 13 | Nick Chubb | Cle @ Dal |
| 14 | Darrell Henderson | LAR vs NYG |
| 15 | James Robinson | Jax @ Cin |
| 16 | Chris Carson (que) | Sea @ Mia |
| 17 | Mike Davis | Car vs Ari |
| 18 | Todd Gurley | Atl @ GB |
| 19 | Ronald Jones | TB vs LAC |
| 20 | David Montgomery (GTD) | Chi vs Ind |
| Rank | Player | Match |
| 21 | Jerick McKinnon | SF vs Phi |
| 22 | Myles Gaskin | Mia vs Sea |
| 23 | Devin Singletary | Buf @ LV |
| 24 | Kareem Hunt (GTD) | Cle @ Dal |
| 25 | Mark Ingram | Bal @ Wsh |
| 26 | Sony Michel | NE @ KC |
| 27 | Antonio Gibson | Wsh vs Bal |
| 28 | Adrian Peterson | Det vs NO |
| 29 | Devonta Freeman | NYG @ LAR |
| 30 | Latavius Murray | NO @ Det |
| 31 | Nyheim Hines | Ind @ Chi |
| 32 | Jeff Wilson | SF vs Phi |
| 33 | Zack Moss (GTD) | Buf @ LV |
| 34 | James White | NE @ KC |
| 35 | Joshua Kelley | LAC @ TB |
| 36 | Rex Burkhead | NE @ KC |
| 37 | Duke Johnson | Hou vs Min |
| 38 | Jamaal Williams | GB vs Atl |
| 39 | Chris Thompson | Jax @ Cin |
| 40 | Giovani Bernard | Cin vs Jax |
