Other position ranks are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Thu 3:13 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs LV |
| 2 | Ezekiel Elliott | Dal @ LAR |
| 3 | Alvin Kamara | NO vs TB |
| 4 | Saquon Barkley | NYG vs Pit |
| 5 | Derrick Henry | Ten @ Den |
| 6 | Dalvin Cook | Min vs GB |
| 7 | Josh Jacobs | LV @ Car |
| 8 | Clyde Edwards-Helaire | KC vs Hou |
| 9 | Austin Ekeler | LAC @ Cin |
| 10 | Miles Sanders (que) | Phi @ Wsh |
| 11 | Joe Mixon (GTD) | Cin vs LAC |
| 12 | James Conner | Pit @ NYG |
| 13 | Kenyan Drake | Ari @ SF |
| 14 | Aaron Jones | GB @ Min |
| 15 | Chris Carson | Sea @ Atl |
| 16 | Todd Gurley | Atl vs Sea |
| 17 | Nick Chubb (GTD) | Cle @ Bal |
| 18 | David Johnson | Hou @ KC |
| 19 | Raheem Mostert | SF vs Ari |
| 20 | Le'Veon Bell | NYJ @ Buf |
| Rank | Player | Match |
| 21 | Melvin Gordon | Den vs Ten |
| 22 | Jonathan Taylor | Ind @ Jax |
| 23 | Mark Ingram | Bal vs Cle |
| 24 | Devin Singletary | Buf vs NYJ |
| 25 | James White | NE vs Mia |
| 26 | David Montgomery (que) | Chi @ Det |
| 27 | Kerryon Johnson | Det vs Chi |
| 28 | Ronald Jones | TB @ NO |
| 29 | Marlon Mack | Ind @ Jax |
| 30 | Jordan Howard | Mia @ NE |
| 31 | Tarik Cohen | Chi @ Det |
| 32 | D'Andre Swift (que) | Det vs Chi |
| 33 | Chris Thompson | Jax vs Ind |
| 34 | Sony Michel | NE vs Mia |
| 35 | Zack Moss | Buf vs NYJ |
| 36 | Leonard Fournette | TB @ NO |
| 37 | J.K. Dobbins | Bal vs Cle |
| 38 | Kareem Hunt | Cle @ Bal |
| 39 | Matt Breida | Mia @ NE |
| 40 | Latavius Murray | NO vs TB |
