These rankings were updated as of Sun 8:54 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car vs NO |
| 2 | Ezekiel Elliott | Dal vs Wsh |
| 3 | Aaron Jones | GB @ Det |
| 4 | Michael Thomas | NO @ Car |
| 5 | Saquon Barkley | NYG vs Phi |
| 6 | Alvin Kamara | NO @ Car |
| 7 | Julio Jones (GTD) | Atl @ TB |
| 8 | Davante Adams | GB @ Det |
| 9 | Derrick Henry | Ten @ Hou |
| 10 | George Kittle | SF @ Sea |
| 11 | Nick Chubb | Cle @ Cin |
| 12 | Tyreek Hill | KC vs LAC |
| 13 | Travis Kelce | KC vs LAC |
| 14 | Miles Sanders | Phi @ NYG |
| 15 | Le'Veon Bell | NYJ @ Buf |
| 16 | Kenyan Drake | Ari @ LAR |
| 17 | Joe Mixon | Cin vs Cle |
| 18 | Marlon Mack | Ind @ Jax |
| 19 | Amari Cooper | Dal vs Wsh |
| 20 | Julian Edelman (que) | NE vs Mia |
| 21 | DeAndre Washington | Oak @ Den |
| 22 | Courtland Sutton | Den vs Oak |
| 23 | Devonta Freeman | Atl @ TB |
| 24 | Phillip Lindsay | Den vs Oak |
| 25 | Austin Ekeler | LAC @ KC |
| 26 | Keenan Allen | LAC @ KC |
| 27 | A.J. Brown | Ten @ Hou |
| 28 | Melvin Gordon | LAC @ KC |
| 29 | Allen Robinson | Chi @ Min |
| 30 | Kenny Golladay | Det vs GB |
| 31 | Breshad Perriman | TB vs Atl |
| 32 | Dallas Goedert | Phi @ NYG |
| 33 | Tyler Lockett | Sea vs SF |
| 34 | Sony Michel (que) | NE vs Mia |
| 35 | Tyler Boyd | Cin vs Cle |
| Rank | Player | Match |
| 36 | DeAndre Hopkins (que) | Hou vs Ten |
| 37 | Raheem Mostert | SF @ Sea |
| 38 | Jarvis Landry | Cle @ Cin |
| 39 | Michael Gallup | Dal vs Wsh |
| 40 | Damien Williams | KC vs LAC |
| 41 | DeVante Parker | Mia @ NE |
| 42 | Ryquell Armstead | Jax vs Ind |
| 43 | Sterling Shepard | NYG vs Phi |
| 44 | Ronald Jones | TB vs Atl |
| 45 | Austin Hooper | Atl @ TB |
| 46 | Emmanuel Sanders | SF @ Sea |
| 47 | James White | NE vs Mia |
| 48 | D.J. Chark | Jax vs Ind |
| 49 | Odell Beckham (que) | Cle @ Cin |
| 50 | D.K. Metcalf | Sea vs SF |
| 51 | Todd Gurley | LAR vs Ari |
| 52 | Robert Woods | LAR vs Ari |
| 53 | Darren Waller | Oak @ Den |
| 54 | Greg Ward | Phi @ NYG |
| 55 | Steven Sims | Wsh @ Dal |
| 56 | David Montgomery (GTD) | Chi @ Min |
| 57 | Travis Homer | Sea vs SF |
| 58 | Malcolm Brown | LAR vs Ari |
| 59 | Christian Kirk | Ari @ LAR |
| 60 | Cooper Kupp | LAR vs Ari |
| 61 | Justin Watson | TB vs Atl |
| 62 | Devin Singletary | Buf vs NYJ |
| 63 | John Ross | Cin vs Cle |
| 64 | Jamison Crowder | NYJ @ Buf |
| 65 | Anthony Miller | Chi @ Min |
| 66 | Adrian Peterson | Wsh @ Dal |
| 67 | T.Y. Hilton | Ind @ Jax |
| 68 | Jared Cook | NO @ Car |
| 69 | Mike Boone | Min vs Chi |
| 70 | Mike Williams | LAC @ KC |
