All position rankings are: QB | RB | WR | TE | FLEX | D
These rankings were updated as of Sun 9:30 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | Car @ Atl |
| 2 | Dalvin Cook | Min vs Det |
| 3 | Leonard Fournette | Jax vs LAC |
| 4 | Alvin Kamara | NO vs SF |
| 5 | Derrick Henry | Ten @ Oak |
| 6 | Saquon Barkley | NYG @ Phi |
| 7 | Nick Chubb | Cle vs Cin |
| 8 | Josh Jacobs (que) | Oak vs Ten |
| 9 | Melvin Gordon | LAC @ Jax |
| 10 | Aaron Jones | GB vs Wsh |
| 11 | Todd Gurley | LAR vs Sea |
| 12 | Chris Carson | Sea @ LAR |
| 13 | Miles Sanders | Phi vs NYG |
| 14 | Devonta Freeman | Atl vs Car |
| 15 | Joe Mixon | Cin @ Cle |
| 16 | Kenyan Drake | Ari vs Pit |
| 17 | Marlon Mack | Ind @ TB |
| 18 | Phillip Lindsay | Den @ Hou |
| 19 | Devin Singletary | Buf vs Bal |
| 20 | Austin Ekeler | LAC @ Jax |
| Rank | Player | Match |
| 21 | Mark Ingram | Bal @ Buf |
| 22 | Benny Snell | Pit @ Ari |
| 23 | LeSean McCoy | KC @ NE |
| 24 | James White | NE vs KC |
| 25 | Sony Michel | NE vs KC |
| 26 | Jamaal Williams | GB vs Wsh |
| 27 | Patrick Laird | Mia @ NYJ |
| 28 | Kareem Hunt | Cle vs Cin |
| 29 | Bilal Powell | NYJ vs Mia |
| 30 | Carlos Hyde | Hou vs Den |
| 31 | Bo Scarbrough | Det @ Min |
| 32 | Derrius Guice | Wsh @ GB |
| 33 | Duke Johnson | Hou vs Den |
| 34 | Raheem Mostert | SF @ NO |
| 35 | Ronald Jones | TB vs Ind |
| 36 | Royce Freeman | Den @ Hou |
| 37 | Jaylen Samuels | Pit @ Ari |
| 38 | Matt Breida | SF @ NO |
| 39 | Nyheim Hines | Ind @ TB |
| 40 | Tevin Coleman | SF @ NO |
