These PPR ranks are updated as of Sept. 15.
Other Week 2 Ranks: Top 25 QBs || Top 50 WRs (PPR) || Top 25 TEs
| Rank | Player | Team | Opp |
| 1 | Alvin Kamara | NO | CLE |
| 2 | Todd Gurley | LAR | ARI |
| 3 | Ezekiel Elliott | DAL | NYG |
| 4 | Saquon Barkley | NYG | @DAL |
| 5 | Melvin Gordon | LAC | @BUF |
| 6 | David Johnson | ARI | @LAR |
| 7 | Christian McCaffrey | CAR | @ATL |
| 8 | Dalvin Cook | MIN | @GB |
| 9 | Jordan Howard | CHI | SEA |
| 10 | Kareem Hunt | KC | @PIT |
| 11 | Adrian Peterson | WAS | IND |
| 12 | James Connor | PIT | KC |
| 13 | Lesean McCoy | BUF | LAC |
| 14 | Lamar Miller | HOU | @TEN |
| 15 | Dion Lewis | TEN | HOU |
| 16 | Jay Ajayi | PHI | @TB |
| 17 | Royce Freeman | DEN | OAK |
| 18 | Isaiah Crowell | NYJ | MIA |
| 19 | Carlos Hyde | CLE | @NO |
| 20 | TJ Yeldon | JAX | NE |
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| Rank | Player | Team | Opp |
| 21 | Chris Thompson | WAS | IND |
| 22 | Tarik Cohen | CHI | SEA |
| 23 | Kenyan Drake | MIA | @NYJ |
| 24 | Tevin Coleman | ATL | CAR |
| 25 | Derick Henry | TEN | HOU |
| 26 | Marshawn Lynch | OAK | @DEN |
| 27 | Alfred Morris | SF | DET |
| 28 | Peyton Barber | TB | PHI |
| 29 | James White | NE | @JAX |
| 30 | Rex Burkhead | NE | @JAX |
| 31 | Bilal Powell | NYJ | MIA |
| 32 | Kerryon Johnson | DET | @SF |
| 33 | Jamaal Williams | GB | MIN |
| 34 | Chris Carson | SEA | CHI |
| 35 | Duke Johnson Jr | CLE | @NO |
| 36 | Phillip Lindsay | DEN | OAK |
| 37 | Matt Bredia | SF | DET |
| 38 | Marlon Mack | IND | @WAS |
| 39 | Austin Ekeler | LAR | @BUF |
| 40 | Theo Riddick | DET | @SF |
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