These standard ranks are updated as of Sept. 15.
Other Week 2 Ranks: Top 25 QBs || Top 40 RBs (PPR) || Top 50 WRs (PPR)
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| Rank | Player | Team | Opp |
| 1 | Rob Gronkowski | NE | @JAC |
| 2 | Travis Kelce | KC | @PIT |
| 3 | Jordan Reed | WSH | IND |
| 4 | Evan Engram | NYG | @DAL |
| 5 | Zach Ertz | PHI | @TB |
| 6 | George Kittle | SF | DET |
| 7 | Trey Burton | CHI | SEA |
| 8 | Jack Doyle | IND | @WSH |
| 9 | Jared Cook | OAK | @DEN |
| 10 | Jimmy Graham | GB | MIN |
| 11 | Eric Ebron | IND | @WSH |
| 12 | David Njoku | CLE | @NO |
| 13 | Kyle Rudolph | MIN | @GB |
| 14 | Ben Watson | NO | CLE |
| 15 | Ricky Seals-Jones | ARI | @LAR |
| 16 | Jonnu Smith | TEN | HOU |
| 17 | A. Seferian-Jenkins | JAC | NE |
| 18 | Charles Clay | BUF | LAC |
| 19 | Jesse James | PIT | KC |
| 20 | Austin Hooper | ATL | CAR |
| 21 | O.J. Howard | TB | PHI |
| 22 | Jake Butt | DEN | OAK |
| 23 | Antonio Gates | LAC | @BUF |
| 24 | Ian Thomas | CAR | @ATL |
| 25 | Dallas Goedert | PHI | @TB |
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