Also be sure to take a look at our other Week 12 Ranks: QB WR TE
Ranks are updated as of Nov. 26
| Rank | Player | Team | Opp |
| 1 | Le'Veon Bell | PIT | GB |
| 2 | Mark Ingram | NO | @LAR |
| 3 | Todd Gurley | LAR | NO |
| 4 | Kareem Hunt | KC | BUF |
| 5 | LeSean McCoy | BUF | @KC |
| 6 | Leonard Fournette | JAC | @ARI |
| 7 | Alvin Kamara | NO | @LAR |
| 8 | Tevin Coleman | ATL | TB |
| 9 | Jordan Howard | CHI | @PHI |
| 10 | DeMarco Murray | TEN | @IND |
| 11 | Carlos Hyde | SF | SEA |
| 12 | Christian McCaffrey | CAR | @NYJ |
| 13 | Dion Lewis | NE | MIA |
| 14 | Lamar Miller | HOU | @BAL |
| 15 | Joe Mixon | CIN | CLE |
| 16 | Jay Ajayi | PHI | CHI |
| 17 | Jamaal Williams | GB | @PIT |
| 18 | Marshawn Lynch | OAK | DEN |
| 19 | Duke Johnson | CLE | @CIN |
| 20 | Doug Martin | TB | @ATL |
If you play in a dynasty league, give your team the best chance to win with Chad’s Dynasty Diagnostic service.
| Rank | Player | Team | Opp |
| 21 | Alex Collins | BAL | HOU |
| 22 | Isaiah Crowell | CLE | @CIN |
| 23 | Adrian Peterson | ARI | JAC |
| 24 | Frank Gore | IND | TEN |
| 25 | Rex Burkhead | NE | MIA |
| 26 | Jonathan Stewart | CAR | @NYJ |
| 27 | Corey Clement | PHI | CHI |
| 28 | Kenyan Drake | MIA | @NE |
| 29 | Damien Williams | MIA | @NE |
| 30 | Devontae Booker | DEN | @OAK |
| 31 | J.D. McKissic | SEA | @SF |
| 32 | Derrick Henry | TEN | @IND |
| 33 | Bilal Powell | NYJ | CAR |
| 34 | C.J. Anderson | DEN | @OAK |
| 35 | Danny Woodhead | BAL | HOU |
| 36 | Marlon Mack | IND | TEN |
| 37 | James White | NE | MIA |
| 38 | LeGarrette Blount | PHI | CHI |
| 39 | Tarik Cohen | CHI | @PHI |
| 40 | Elijah McGuire | NYJ | CAR |
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