Also look at these other Week 5 rankings: QB WR TE FLEX
These ranks are updated as of Oct. 8 and will be updated throughout the weekend.
On bye: Broncos, Falcons, Redskins, Saints
| Rank | Player | Team | Opp |
| 1 | Le'Veon Bell | PIT | JAC |
| 2 | Ezekiel Elliott | DAL | GB |
| 3 | Todd Gurley | LAR | SEA |
| 4 | Kareem Hunt | KC | @HOU |
| 5 | LeSean McCoy | BUF | @CIN |
| 6 | Carlos Hyde | SF | @IND |
| 7 | Leonard Fournette | JAC | @PIT |
| 8 | Melvin Gordon | LAC | @NYG |
| 9 | Jay Ajayi | MIA | TEN |
| 10 | DeMarco Murray | TEN | @MIA |
| 11 | Jordan Howard | CHI | MIN |
| 12 | Lamar Miller | HOU | KC |
| 13 | Bilal Powell | NYJ | @CLE |
| 14 | Frank Gore | IND | SF |
| 15 | Joe Mixon | CIN | BUF |
| 16 | Duke Johnson | CLE | NYJ |
| 17 | Marshawn Lynch | OAK | BAL |
| 18 | Ameer Abdullah | DET | CAR |
| 19 | Latavius Murray | MIN | @CHI |
| 20 | Christian McCaffrey | CAR | @DET |
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| Rank | Player | Team | Opp |
| 21 | LeGarrette Blount | PHI | ARI |
| 22 | Jonathan Stewart | CAR | @DET |
| 23 | Tarik Cohen | CHI | MIN |
| 24 | Isaiah Crowell | CLE | NYJ |
| 25 | Wayne Gallman | NYG | LAC |
| 26 | Andre Ellington | ARI | @PHI |
| 27 | Eddie Lacy | SEA | @LAR |
| 28 | Aaron Jones | GB | @DAL |
| 29 | Alex Collins | BAL | @OAK |
| 30 | Javorius Allen | BAL | @OAK |
| 31 | Jonathan Stewart | CAR | @DET |
| 32 | Derrick Henry | TEN | @MIA |
| 33 | Jerick McKinnon | MIN | @CHI |
| 34 | Jamaal Williams | GB | @DAL |
| 35 | Chris Johnson | ARI | @PHI |
| 36 | J.D. McKissic | SEA | @LAR |
| 37 | Elijah McGuire | NYJ | @CLE |
| 38 | Giovani Bernard | CIN | BUF |
| 39 | Kenjon Barner | PHI | ARI |
| 40 | Corey Clement | PHI | ARI |
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