All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 12:05 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey (P) | SF vs NYJ |
| 2 | Bijan Robinson | Atl vs Pit |
| 3 | Breece Hall | NYJ @ SF |
| 4 | Saquon Barkley | Phi vs GB |
| 5 | Jonathan Taylor | Ind vs Hou |
| 6 | Alvin Kamara | NO vs Car |
| 7 | Jahmyr Gibbs | Det vs LAR |
| 8 | Rachaad White | TB vs Wsh |
| 9 | Josh Jacobs | GB @ Phi |
| 10 | Joe Mixon | Hou @ Ind |
| 11 | Derrick Henry | Bal @ KC |
| 12 | James Cook | Buf vs Ari |
| 13 | Kyren Williams | LAR @ Det |
| 14 | Travis Etienne Jr. | Jax @ Mia |
| 15 | De'Von Achane | Mia vs Jax |
| 16 | Kenneth Walker III | Sea vs Den |
| 17 | Isiah Pacheco | KC vs Bal |
| 18 | Aaron Jones | Min @ NYG |
| 19 | Jerome Ford | Cle vs Dal |
| 20 | James Conner | Ari @ Buf |
| Rank | Player | Match |
| 21 | David Montgomery | Det vs LAR |
| 22 | Rhamondre Stevenson | NE @ Cin |
| 23 | Chuba Hubbard | Car @ NO |
| 24 | Zamir White | LV @ LAC |
| 25 | Javonte Williams | Den @ Sea |
| 26 | Raheem Mostert | Mia vs Jax |
| 27 | Devin Singletary | NYG vs Min |
| 28 | Najee Harris | Pit @ Atl |
| 29 | D'Andre Swift | Chi vs Ten |
| 30 | Tony Pollard | Ten @ Chi |
| 31 | Zack Moss | Cin vs NE |
| 32 | Brian Robinson Jr. | Wsh @ TB |
| 33 | Jaylen Warren (Q) | Pit @ Atl |
| 34 | Chase Brown | Cin vs NE |
| 35 | Austin Ekeler | Wsh @ TB |
| 36 | Gus Edwards | LAC vs LV |
| 37 | Tyjae Spears | Ten @ Chi |
| 38 | Ezekiel Elliott | Dal @ Cle |
| 39 | Antonio Gibson | NE @ Cin |
| 40 | J.K. Dobbins | LAC vs LV |
