Other Week 5 Ranks: Top 25 QBs || Top 50 WRs || Top 20 TEs
Build the best lineups with the power of The Machine for Daily Fantasy Sports.
| Rank | Player | Team | Opp |
| 1 | Alvin Kamara | NO | WAS |
| 2 | Ezekiel Elliott | DAL | @HOU |
| 3 | Todd Gurley | LAR | @SEA |
| 4 | Melvin Gordon | LAC | OAK |
| 5 | Christian McCaffrey | CAR | NYG |
| 6 | James Conner | PIT | ATL |
| 7 | Saquon Barkley | NYG | @CAR |
| 8 | David Johnson | ARI | @SF |
| 9 | Joe Mixon | CIN | MIA |
| 10 | T.J. Yeldon | JAC | @KC |
| 11 | Kareem Hunt | KC | JAC |
| 12 | Devonta Freeman | ATL | PIT |
| 13 | Marshawn Lynch | OAK | LAC |
| 14 | Chris Thompson | WAS | @NO |
| 15 | Dalvin Cook | MIN | @PHI |
| 16 | Matt Breida | SF | ARI |
| 17 | Carlos Hyde | CLE | BAL |
| 18 | Jay Ajayi | PHI | MIN |
| 19 | Adrian Peterson | WAS | @NO |
| 20 | Lamar Miller* | HOU | DAL |
Build the best lineups with the power of The Machine for Daily Fantasy Sports.
| Rank | Player | Team | Opp |
| 21 | Dion Lewis | TEN | @BUF |
| 22 | Alex Collins | BAL | @CLE |
| 23 | Phillip Lindsay | DEN | @NYJ |
| 24 | Tevin Coleman | ATL | @PIT |
| 25 | Kerryon Johnson | DET | GB |
| 26 | Royce Freeman | DEN | @NYJ |
| 27 | LeSean McCoy | BUF | TEN |
| 28 | Aaron Jones | GB | @DET |
| 29 | Mark Ingram | NO | WAS |
| 30 | Chris Carson | SEA | LAR |
| 31 | Bilal Powell | NYJ | DEN |
| 32 | Javorius Allen | BAL | @CLE |
| 33 | Derrick Henry | TEN | @BUF |
| 34 | Frank Gore | MIA | @CIN |
| 35 | Austin Ekeler | LAC | OAK |
| 36 | Isaiah Crowell | NYJ | DEN |
| 37 | Alfred Morris | SF | ARI |
| 38 | Ty Montgomery | GB | @DET |
| 39 | Nick Chubb | CLE | BAL |
| 40 | Corey Grant | JAC | @KC |
*Assuming the player plays.
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